Treatment of Children with Juvenile Myelomonocytic Leukemia (JMML)
Juvenile myelomonocytic leukemia (JMML) is rare so it has been hard to study which treatment might be best. There is no clear single best chemotherapy treatment for this leukemia.
Common treatment approaches for JMML
A stem cell transplant is the treatment of choice when possible, as it offers the best chance to cure JMML. Sometimes, even if the leukemia recurs, a second stem cell transplant can be helpful.
Because JMML is hard to treat with current chemo drugs, taking part in a clinical trial looking at newer drugs may be a good option for children who cannot get a stem cell transplant.
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- References
Developed by the 91黑料不打烊 medical and editorial content team with medical review and contribution by the American Society of Clinical Oncology (ASCO).
National Cancer Institute. Juvenile Myelomonocytic Leukemia Treatment (PDQ). 2024. Accessed at https://www.cancer.gov/types/leukemia/hp/child-aml-treatment-pdq/childhood-jmml-treatment-pdq on May 12, 2025.
Niemeyer CM, Flotho C, Lipka DB, et al. Response to upfront azacitidine in juvenile myelomonocytic leukemia in the AZA-JMML-001 trial. Blood Adv. 2021;5(14):2901-2908.
Rau RE, Loh ML. Chapter 17B: Myeloproliferative Neoplasms of Childhood. In: Blaney SM, Adamson PC, Helman LJ, eds. Pizzo and Poplack’s Pediatric Oncology. 8th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2021.
Last Revised: July 22, 2025
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